Stinging Nettle Root Extract (10:1) — 750mg Capsules (7,500mg Raw Root Equivalent)

Understanding True Herbal Potency

When shopping for natural supplements, you often encounter numbers that can be confusing: milligrams, concentration ratios, and equivalent amounts. These numbers, however, are critical—they tell you exactly how potent your supplement is and whether it contains the scientifically relevant dose to deliver results for issues like prostate health and inflammation ^{[1, 3]}.

A product like a 750mg Stinging Nettle Root Extract standardized to a 10:1 concentration ratio represents one of the most potent forms available. This article breaks down what those numbers mean and why this high concentration is necessary for maximum efficacy.

1. Decoding the 10:1 Concentration Ratio

The concentration ratio, often labeled as DER (Drug to Extract Ratio), is the most important indicator of potency for an extract. It dictates how much raw plant material was used to create the final concentrated powder.

• The Raw Material: The starting point is 10 parts of high-quality Stinging Nettle Root ^[4], which contains the beneficial lignans, phytosterols, and lectins ^{[5, 6]}.
• The Extraction Process: This material is carefully processed using solvents (like alcohol or water) to strip away fiber and bulk, concentrating the active compounds that are beneficial for prostate health ^{[3, 7]}.
• The Final Product: The process yields 1 part of highly concentrated extract

In short: 10 pounds of raw root yields 1 pound of 10:1 extract. This concentration is vital because the active components in the root are highly concentrated and less abundant than the nutrients found in the nettle leaf ^[2].

2. Calculating the Raw Root Equivalent

The "Raw Root Equivalent" translates the potency on the label into simple, comparative terms. This helps you understand the therapeutic strength of the capsule.

A single 750mg 10:1 capsule delivers the active principles equivalent to consuming 7,500 milligrams (or 7.5 grams) of dried, raw nettle root powder. This level of concentration ensures you are getting a biologically active dose far beyond what low-ratio or simple dried powder capsules can provide.

3. Linking Potency to Clinical Efficacy

Clinical trials that demonstrated significant benefits for prostate health used highly concentrated extracts, aligning with the potency of a 10:1 ratio:

• BPH Symptom Relief: Clinical studies have repeatedly used concentrated nettle root extracts to show marked improvements in urinary flow and a reduction in symptoms of Benign Prostatic Hyperplasia (BPH) ^{[1, 9]}. One key German multicenter study used an extract dose (Bazoton-uno) comparable in active strength to this high-potency formula ^[11].
• Anti-Inflammatory Power: Highly concentrated extracts have been shown to possess potent anti-inflammatory activity, making this form optimal for conditions like arthritis and general inflammatory disorders ^{[7, 10]}.
• SHBG Modulation: The compounds responsible for interacting with Sex Hormone Binding Globulin (SHBG)—which helps increase free testosterone—are best captured and concentrated via effective extraction methods ^[3].

4. Why Choose High-Concentration Extracts?

Opting for a high-concentration extract like 10:1 over standard raw herb powder is essential for therapeutic results:

• Reliable Dosing: Extracts minimize the natural variability found in raw herbs, ensuring a consistent dose of key compounds in every capsule ^[6].
• Targeted Compounds: Specialized extraction processes prioritize the root’s lipophilic compounds (like phytosterols), which are poorly soluble in water and are crucial for the antiproliferative effects in the prostate ^[5].
• Reduced Capsule Count: Instead of swallowing 10 large capsules of raw powder (7,500mg), you receive the equivalent therapeutic dose in a single, convenient 750mg extract capsule.

Scientific Credibility & Citations

1. Chrubasik JE, Roufogalis BD, Wagner H, Chrubasik S. A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: urticae radix. *Phytomedicine*. 2007. PMID: 17509841 (Review)
2. Bhusal KK, Magar SK, et al. Nutritional and pharmacological importance of stinging nettle (*Urtica dioica* L.): A review. *Heliyon*. 2022. PMID: 35800714 (Review, Phytochemistry)
3. The effect of extracts of the roots of the stinging nettle (*Urtica dioica*) on the interaction of SHBG with its receptor on human prostatic membranes. *Planta Med*. 1995. PMID: 7700987 (Mechanistic, SHBG)
4. Martz F, Kankaanpää S. Stinging Nettle (*Urtica dioica*) Roots: The Power Underground—A Review. *Plants (Basel)*. 2025. PMID: 39861633 (Review, Root Compounds)
5. Johnson TA, Sohn J, et al. Lipophilic stinging nettle extracts possess potent anti-inflammatory activity... *Phytomedicine*. 2013. PMID: 23092723 (In vitro, Anti-inflammatory)
6. Lichius JJ, Muth C. The inhibiting effects of *Urtica dioica* root extracts on experimentally induced prostatic hyperplasia in the mouse. *Planta Med*. 1997. PMID: 9270373 (Animal, Anti-hyperplasia)
7. Urtica Dioica Root Extract on Clinical and Biochemical Parameters in BPH Patients. *Phytother Res*. 2020. PMID: 32981268 (Clinical trial, BPH)
8. [Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome...]. *Urologe A*. 2004. PMID: 15045190 (Clinical trial, BPH, Dosage context)